Sustratos de oro para el desarrollo de biosensores para la seguridad alimentaria: Avances y Perspectivas

Authors

  • Dulce Carmina Sánchez Rangel Universidad Autónoma de Coahuila
  • Arxel De León Santillán Autonomous University of Coahuila image/svg+xml
  • Cynthia Lizeth Barrera Martinez Autonomous University of Coahuila image/svg+xml
  • Roberto Arredondo Valdés Autonomous University of Coahuila image/svg+xml
  • Antonio Serguei Ledezma Pérez Autonomous University of Coahuila image/svg+xml
  • ELAN IÑAKY LAREDO ALCALÁ Autonomous University of Coahuila image/svg+xml

DOI:

https://doi.org/10.19136/jeeos.a10n1.6684

Keywords:

Biosensores, Sustratos de oro, nanopartículas, Seguridad Alimentaria, Detección de Contaminantes

Abstract

La seguridad alimentaria es una preocupación global; cada año aproximadamente 600 millones de personas se enferman debido a alimentos contaminados, causando cerca de 500 000 muertes. Las técnicas analíticas tradicionales de detección presentan limitaciones de tiempo, costo y precisión, lo que impulsa la búsqueda de tecnologías más eficaces para monitorear contaminantes y patógenos en los alimentos. En este escenario, los biosensores basados en oro han surgido como un enfoque eficaz, debido a las propiedades únicas del oro, incluyendo su biocompatibilidad, conductividad y capacidad para inmovilizar biomoléculas, permiten mejorar la sensibilidad, estabilidad y eficiencia de los sistemas de detección. Este artículo revisa los avances recientes en el desarrollo de biosensores de oro aplicados a la seguridad alimentaria, destacando su potencial para la detección rápida y precisa de contaminantes y su contribución a estándares más altos de inocuidad alimentaria.

References

[1] Onyeaka-H, Ghosh-S, Obileke-K, Miri-T, Odeyemi-OA, Nwaiwu-O, Tamasiga-P (2024). Preventing chemical contaminants in food: Challenges and prospects for safe and sustainable food production, Food Control, 155, 110 040.

[2] Shuai-Y, Sui-H, Tao-G, Huo-Q, Li-C, Shao-N (2022). Food Contaminants, Nutritional Toxicology, 107–166.

[3] Kato-LS, Conte-Junior-CA (2021). Safety of Plastic Food Packaging: The Challenges about Non-Intentionally Added Substances (NIAS) Discovery, Identification and Risk Assessment, Polymers, 13(13), 13.

[4] Alam-S, Nisa-S, Daud-S (2022). Mycotoxins in Environment and Its Health Implications, Hazardous Environmental Micro-pollutants, Health Impacts and Allied Treatment Technologies, 289–318.

[5] Sarker-A, Kim-JE, Islam-ARMT, Bilal-M, Rakib-MRJ, Nandi-R, Rahman-MM, Islam-T (2022). Heavy metals contamination and associated health risks in food webs—A review focuses on food safety and environmental sustainability in Bangladesh, Environmental Science and Pollution Research, 29(3), 3230–3245.

[6] Salamah-IU, Laraba-TF, David-BJ, Mercy-N (2024). International regulations in food contaminants, Emerging contaminants in food and food products, 29–43.

[7] Lee-JG, Lee-Y, Kim-CS, Han-SB (2021). Codex Alimentarius commission on ensuring food safety and promoting fair trade: Harmonization of standards between Korea and codex, Food Science and Biotechnology, 30(9), 1151–1170

[8] Bhavadharini-B, Kavimughil-M, Malini-B, Vallath-A, Prajapati-HK, Sunil-CK (2022). Recent Advances in Biosensors for Detection of Chemical Contaminants in Food—A Review, Food Analytical Methods, 15(6), 1545–1564.

[9] Sheng-K, Jiang-H, Fang-Y, Wang-L, Jiang-D (2022). Emerging electrochemical biosensing approaches for detection of allergen in food samples: A review, Trends in Food Science & Technology, 121, 93–104.

[10] Zhang-J, Huang-H, Song-G, Huang-K, Luo-Y, Liu-Q, He-X, Cheng-N (2022). Intelligent biosensing strategies for rapid detection in food safety: A review, Biosensors and Bioelectronics, 202, 114003.

[11] Shaltout-FA (2024). New Ways to Avoid Hazards in Human Food, Int J Spine Surg Res, 1(1), 1–7.

[12] Lebelo-K, Malebo-N, Mochane-MJ, Masinde-M (2021). Chemical Contamination Pathways and the Food Safety Implications along the Various Stages of Food Production: A Review, International Journal of Environmental Research and Public Health, 18(11), 11.

[13] Onyeaka-H, Ghosh-S, Obileke-K, Miri-T, Odeyemi-OA, Nwaiwu-O, Tamasiga-P (2024). Preventing chemical contaminants in food: Challenges and prospects for safe and sustainable food production, Food Control, 155, 110040.

[14] Shuai-Y, Sui-H, Tao-G, Huo-Q, Li-C, Shao-N (2022). Food Contaminants, Nutritional Toxicology, 107–166.

[15] Huo-B, Hu-Y, Gao-Z, Li-G (2021). Recent advances on functional nucleic acid-based biosensors for detection of food contaminants, Talanta, 222, 121565.

[16] Li-H, Sheng-W, Haruna-SA, Bei-Q, Wei-W, Hassan-MM, Chen-Q (2023). Recent progress in photoelectrochemical sensors to quantify pesticides in foods: Theory, photoactive substrate selection, recognition elements and applications, TrAC Trends in Analytical Chemistry, 164, 117108.

[17] Tudi-M, Daniel Ruan-H, Wang-L, Lyu-J, Sadler-R, Connell-D, Chu-C, Phung-DT (2021). Agriculture Development, Pesticide Application and Its Impact on the Environment, International Journal of Environmental Research and Public Health, 18(3), 3.

[18] Fucic-A, Duca-RC, Galea-KS, Maric-T, Garcia-K, Bloom-MS, Vena-JE (2021). Reproductive health risks associated with occupational and environmental exposure to pesticides, International Journal of Environmental Research and Public Health, 18(12), 6576.

[19] Briffa-J, Sinagra-E, Blundell-R (2020). Heavy metal pollution in the environment and their toxicological effects on humans, Heliyon, 6(9).

[20] Piwowarska-D, Kiedrzyńska-E, Jaszczyszyn-K (2024). A global perspective on the nature and fate of heavy metals polluting water ecosystems, and their impact and remediation, Critical Reviews in Environmental Science and Technology, 54(19), 1436–1458.

[21] Rawat-H, Bhat-SA, Dhanjal-DS, Singh-R, Gandhi-Y, Mishra-SK, Kumar-V, Shakya-SK, Narasimhaji-CV, Singh-A, Singh-R, Acharya-R (2024). Emerging techniques for the trace elemental analysis of plants and food-based extracts: A comprehensive review, Talanta Open, 10, 100341.

[22] Ali-MM, Hossain-D, Al-Imran-KMS, Begum-M, Osman-MH (2021). Environmental Pollution with Heavy Metals: A Public Health Concern, Heavy Metals—Their Environmental Impacts and Mitigation.

[23] Briffa-J, Sinagra-E, Blundell-R (2020). Heavy metal pollution in the environment and their toxicological effects on humans, Heliyon, 6(9).

[24] De Girolamo-A, Lippolis-V, Pascale-M (2022). Overview of Recent Liquid Chromatography Mass Spectrometry-Based Methods for Natural Toxins Detection in Food Products, Toxins, 14(5), 5.

[25] Tang-X, Zuo-J, Yang-C, Jiang-J, Zhang-Q, Ping-J, Li-P (2023). Current trends in biosensors for biotoxins (mycotoxins, marine toxins, and bacterial food toxins): principles, application, and perspective, TrAC Trends in Analytical Chemistry, 165, 117144.

[26] Awuchi-CG, Ondari-EN, Nwozo-S, Odongo-GA, Eseoghene-IJ, Twinomuhwezi-H, Ogbonna-CU, Upadhyay-AK, Adeleye-AO, Okpala-COR (2022). Mycotoxins’ Toxicological Mechanisms Involving Humans, Livestock and Their Associated Health Concerns: A Review, Toxins, 14(3), 3.

[27] Ganesan-AR, Mohan-K, Karthick Rajan-D, Pillay-AA, Palanisami-T, Sathishkumar-P, Conterno-L (2022). Distribution, toxicity, interactive effects, and detection of ochratoxin and deoxynivalenol in food: A review, Food Chemistry, 378, 131978.

[28] Peivasteh-Roudsari-L, Pirhadi-M, Shahbazi-R, Eghbaljoo-Gharehgheshlaghi-H, Sepahi-M, Mirza Alizadeh-A, Tajdar-oranj-B, Jazaeri-S (2022). Mycotoxins: Impact on Health and Strategies for Prevention and Detoxification in the Food Chain, Food Reviews International, 38(sup1), 193–224.

[29] Mkangara-M (2023). Prevention and Control of Human Salmonella enterica Infections: An Implication in Food Safety, International Journal of Food Science, 2023(1), 8899596.

[30] Tiwari-A, Nagalli-S (2024). Clostridium botulinum Infection (Archived), StatPearls.

[31] Yada-EL, Menta-YD (2023). Review on Prevalence of Bacillus cereus Enterotoxigenic Genes Isolated from Food of Animal Origin and its Public Health Significance, World Journal of Dairy & Food Sciences, 18(2), 16–23.

[32] Vasavada-PC, Lee-A, Betts-R (2020). Conventional and novel rapid methods for detection and enumeration of microorganisms, Food Safety Engineering, 85–128.

[33] Haque-F, Bubli-SY, Khan-MS (2021). UV–Vis Spectroscopy for Food Analysis, Techniques to Measure Food Safety and Quality: Microbial, Chemical, and Sensory, 169–193.

[34] Qi-W, Tian-Y, Lu-D, Chen-B (2022). Research Progress of Applying Infrared Spectroscopy Technology for Detection of Toxic and Harmful Substances in Food, Foods, 11(7), 7.

[35] Caño-Carrillo-I, Gilbert-López-B, Montero-L, Martínez-Piernas-AB, García-Reyes-JF, Molina-Díaz-A (2024). Comprehensive and heart-cutting multidimensional liquid chromatography–mass spectrometry and its applications in food analysis, Mass Spectrometry Reviews, 43(5), 936–976.

[36] Vargas Medina-DA, Bassolli Borsatto-JV, Maciel-EVS, Lanças-FM (2021). Current role of modern chromatography and mass spectrometry in the analysis of mycotoxins in food, TrAC Trends in Analytical Chemistry, 135, 116156.

[37] Hong-SP (2024). Detecting agri contaminants via nanomaterial immunosensors, Food and Humanity, 3, 100325.

[38] Li-R, Wen-Y, Wang-F, He-P (2021). Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods, Journal of Animal Science and Biotechnology, 12(1), 108.

[39] Abolghait-SK, Fathi-AG, Youssef-FM, Algammal-AM (2020). Methicillin-resistant Staphylococcus aureus (MRSA) isolated from chicken meat and giblets often produces staphylococcal enterotoxin B (SEB) in non-refrigerated raw chicken livers, International Journal of Food Microbiology, 328, 108669.

[40] Ferone-M, Gowen-A, Fanning-S, Scannell-AGM (2020). Microbial detection and identification methods: Bench top assays to omics approaches, Comprehensive Reviews in Food Science and Food Safety, 19(6), 3106–3129.

[41] Bhaiyya-M, Panigrahi-D, Rewatkar-P, Haick-H (2024). Role of machine learning assisted biosensors in point-of-care-testing for clinical decisions, ACS Sensors, 9(9), 4495–4519.

[42] Zhang-L, Yang-Q, Zhu-Z (2024). The Application of Multi-Parameter Multi-Modal Technology Integrating Biological Sensors and Artificial Intelligence in the Rapid Detection of Food Contaminants, Foods, 13(12), 12.

[43] Chadha-U, Bhardwaj-P, Agarwal-R, Rawat-P, Agarwal-R, Gupta-I, Panjwani-M, Singh-S, Ahuja-C, Selvaraj-SK, Banavoth-M, Sonar-P, Badoni-B, Chakravorty-A (2022). Recent progress and growth in biosensors technology: A critical review, Journal of Industrial and Engineering Chemistry, 109, 21–51.

[44] Karunakaran-R, Keskin-M (2022). Chapter 11 - Biosensors: Components, mechanisms, and applications, Analytical Techniques in Biosciences, 179–190.

[45] Polat-EO, Cetin-MM, Tabak-AF, Bilget Güven-E, Uysal-BÖ, Arsan-T, Gül-SB (2022). Transducer technologies for biosensors and their wearable applications, Biosensors, 12(6), 385.

[46] Feyziazar-M, Amini-M, Jahanban-Esfahlan-A, Baradaran-B, Oroojalian-F, Kamrani-A, de la Guardia-M (2022). Recent advances on the piezoelectric, electrochemical, and optical biosensors for the detection of protozoan pathogens, TrAC Trends in Analytical Chemistry, 157, 116803.

[47] Sim-D, Brothers-MC, Slocik-JM, Islam-AE, Maruyama-B, Grigsby-CC, Naik-RR, Kim-SS (2022). Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review, Advanced Science, 9(7), 2104426.

[48] Lupu-LM, Wiegand-P, Holdschick-D, Mihoc-D, Maeser-S, Rawer-S, Przybylski-M (2021). Identification and affinity determination of protein-antibody and protein-aptamer epitopes by biosensor-mass spectrometry combination, International Journal of Molecular Sciences, 22(23), 12832.

[49] Bucur-B, Purcarea-C, Andreescu-S, Vasilescu-A (2021). Addressing the Selectivity of Enzyme Biosensors: Solutions and Perspectives, Sensors, 21(9), 9.

[50] Zhang-C, Zhao-Y, Xu-X, Xu-R, Li-H, Teng-X, Han-D (2020). Cancer diagnosis with DNA molecular computation, Nature Nanotechnology, 15(8), 709–715.

[51] Zhu-J, Wang-B, Zhang-Y, Wei-T, Gao-T (2023). Living electrochemical biosensing: Engineered electroactive bacteria for biosensor development and the emerging trends, Biosensors and Bioelectronics, 237, 115480.

[52] Huang-X, Zhu-Y, Kianfar-E (2021). Nano biosensors: properties, applications and electrochemical techniques, Journal of Materials Research and Technology, 12, 1649–1672.

[53] Zhao-W, Chen-HY, Xu-JJ (2021). Electrogenerated chemiluminescence detection of single entities, Chemical Science, 12(16), 5720–5736.

[54] De Acha-N, Socorro-Leránoz-AB, Elosúa-C, Matías-IR (2021). Trends in the Design of Intensity-Based Optical Fiber Biosensors (2010–2020), Biosensors, 11(6), 6.

[55] Durdaut-P, Höft-M (2023). Performance Analysis of Resonantly Driven Piezoelectric Sensors Operating in Amplitude Mode and Phase Mode, Sensors, 23(4), 4.

[56] Naresh-V, Lee-N (2021). A review on biosensors and recent development of nanostructured materials-enabled biosensors, Sensors, 21(4), 1109.

[57] Naresh-V, Lee-N (2021). A review on biosensors and recent development of nanostructured materials-enabled biosensors, Sensors, 21(4), 1109.

[58] Iftikhar-FJ, Shah-A, Wali-Q, Kokab-T (2023). Advancements in nanofiber-based electrochemical biosensors for diagnostic applications, Biosensors, 13(4), 416.

[59] Dolai-J, Mandal-K, Jana-NR (2021). Nanoparticle size effects in biomedical applications, ACS Applied Nano Materials, 4(7), 6471–6496.

[60] Awan-TI, Afsheen-S, Mushtaq-A (2025). Overview of Noble Metals, Influence of Noble Metal Nanoparticles in Sustainable Energy Technologies, 49–78.

[61] Feng-L, Song-S, Li-H, He-R, Chen-S, Wang-J, Zhao-X (2023). Nano-biosensors based on noble metal and semiconductor materials: emerging trends and future prospects, Metals, 13(4), 792.

[62] Sati-A, Mali-SN, Samdani-N, Annadurai-S, Dongre-R, Satpute-N, Pratap-AP (2025). From past to present: Gold nanoparticles (AuNPs) in daily life─synthesis mechanisms, influencing factors, characterization, toxicity, and emerging applications in biomedicine, nanoelectronics, and materials science, ACS Omega, 10(31), 33999–34087.

[63] Ielo-I, Rando-G, Giacobello-F, Sfameni-S, Castellano-A, Galletta-M, Plutino-MR (2021). Synthesis, chemical–physical characterization, and biomedical applications of functional gold nanoparticles: a review, Molecules, 26(19), 5823.

[64] Zhuang-L, Lian-Y, Zhu-T (2025). Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer, Molecular Cancer, 24(1), 228.

[65] Karnwal-A, Kumar-Sachan-RS, Devgon-I, Devgon-J, Pant-G, Panchpuri-M, Kumar-G (2024). Gold nanoparticles in nanobiotechnology: from synthesis to biosensing applications, ACS Omega, 9(28), 29966–29982.

[66] Xiao-Y, Wu-Z, Yao-Q, Xie-J (2021). Luminescent metal nanoclusters: Biosensing strategies and bioimaging applications, Aggregate, 2(1), 114–132.

[67] Nasrollahpour-H, Sanchez-BJ, Sillanpaa-M, Moradi-R (2023). Metal nanoclusters in point-of-care sensing and biosensing applications, ACS Applied Nano Materials, 6(14), 12609–12672.

[68] Maity-S, Kolay-S, Chakraborty-S, Devi-A, Patra-A (2025). A comprehensive review of atomically precise metal nanoclusters with emergent photophysical properties towards diverse applications, Chemical Society Reviews.

[69] Halicka-K, Cabaj-J (2021). Electrospun nanofibers for sensing and biosensing applications—a review, International Journal of Molecular Sciences, 22(12), 6357.

[70] Kang-S, Zhao-K, Yu-DG, Zheng-X, Huang-C (2022). Advances in biosensing and environmental monitoring based on electrospun nanofibers, Advanced Fiber Materials, 4(3), 404–435.

[71] Rather-AH, Khan-RS, Wani-TU, Beigh-MA, Sheikh-FA (2022). Overview on immobilization of enzymes on synthetic polymeric nanofibers fabricated by electrospinning, Biotechnology and Bioengineering, 119(1), 9–33.

[72] Khan-RS, Rather-AH, Wani-TU, Rather-SU, Amna-T, Hassan-MS, Sheikh-FA (2023). Recent trends using natural polymeric nanofibers as supports for enzyme immobilization and catalysis, Biotechnology and Bioengineering, 120(1), 22–40.

[73] Aditya-DS, Nataraj-SK (2024). Structural, optical, and electronic properties of two‐dimensional nanomaterials, Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites: Processing, Properties and Applications, 167–194.

[74] Fatma-I, Assad-H, Kumar-A (2024). Introduction to two‐dimensional nanomaterials: discovery, types and classifications, structure, unique properties, and applications, Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites: Processing, Properties and Applications, 1–45.

[75] Li-R, Li-L, Huang-T, Liu-X, Chen-Q, Jin-G, Cao-H (2021). Gold nanoparticle-based colorimetric aptasensor for rapid detection of multiple mycotoxins in rice, Analytical Methods, 13(47), 5749–5755.

[76] Naghshbandi-B, Adabi-M, Pooshang-Bagheri-K, Tavakolipour-H (2022). Design of a new electrochemical aptasensor based on screen printed carbon electrode modified with gold nanoparticles for the detection of fumonisin B1 in maize flour, Journal of Nanobiotechnology, 20(1), 534.

[77] Xu-C, Lin-M, Song-C, Chen-D, Bian-C (2022). A gold nanoparticle-based visual aptasensor for rapid detection of acetamiprid residues in agricultural products using a smartphone, RSC Advances, 12(9), 5540–5545.

[78] Yang-D, Hui-Y, Liu-Y, Wang-W, He-C, Zhao-A, ... & Wang-B (2024). Novel dual-recognition electrochemical biosensor for the sensitive detection of AFM1 in milk, Food Chemistry, 433, 137362.

[79] Park-SH, You-Y (2023). Gold nanoparticle-based colorimetric biosensing for foodborne pathogen detection, Foods, 13(1), 95.

[80] Karnwal-A, Kumar-Sachan-RS, Devgon-I, Devgon-J, Pant-G, Panchpuri-M, ... & Kumar-G (2024). Gold nanoparticles in nanobiotechnology: from synthesis to biosensing applications, ACS Omega, 9(28), 29966–29982.

[83] Sharifi-S, Reuel-N, Kallmyer-N, Sun-E, Landry-MP, Mahmoudi-M (2022). The issue of reliability and repeatability of analytical measurement in industrial and academic nanomedicine, ACS Nano, 17(1), 4–11.

[84] Zhao, Y., Sun, T., Zhang, H., Lian, C., Zhao, Z., Jiang, Y., ... & Chen, S. (2025). Artificial intelligence enhanced electrochemical immunoassay for staphylococcal enterotoxin B. Scientific Reports, 15(1), 19602.

[85] Baker-DV, Bernal-Escalante-J, Traaseth-C, Wang-Y, Tran-MV, Keenan-S, Algar-WR (2025). Smartphones as a platform for molecular analysis: concepts, methods, devices and future potential, Lab on a Chip.

[86] Xing-E, Chen-H, Xin-X, Cui-H, Dou-Y, Song-S (2025). Recent advances in smart phone-based biosensors for various applications, Chemosensors, 13(7), 221.

[87] Azodo-AP, Mezue-TC, Omokaro-I (2025). Smartphone-based biosensors: current trends, challenges, and future prospects, Engineering Proceedings, 106(1), 10.

[88] Al-Shawi-SG, Nasser-EK, Kareem-AK, Suliman-M, Shankar-A, Ray-S, ... & Hulail-HM (2025). Smartphone-integrated lateral flow assays for food safety assessment: recent trends and future perspectives, Microchemical Journal, 113978.

Additional Files

Published

2026-04-30

Issue

Section

ARTÍCULO DE REVISIÓN

How to Cite

Sánchez Rangel, D. C., De León Santillán, A., Barrera Martinez, C. L., Arredondo Valdés, R., Ledezma Pérez, A. S., & LAREDO ALCALÁ, E. I. (2026). Sustratos de oro para el desarrollo de biosensores para la seguridad alimentaria: Avances y Perspectivas. Journal of Energy, Engineering Optimization and Sustainability, 10(1), 47-62. https://doi.org/10.19136/jeeos.a10n1.6684